Human Gingival Fibroblast Injury by Polymorphonuclear Leukocytes Exposed to Oral Microorganisms.
نویسندگان
چکیده
منابع مشابه
Human Polymorphonuclear Leukocytes
A B S T R A C T Acetyl glyceryl ether phosphorylcholine (AGEPC) and leukotriene B4 (LTB4) induce concentration-dependent neutrophil aggregation. On a molar basis, LTB4 is 10 to 100 times more potent than AGEPC. AGEPC-induced aggregation is attenuated by two inhibitors of arachidonate lipoxygenation, eicosatetraynoic acid and nordihydroguaiaretic acid, and to a lesser extent by the cyclooxygenas...
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Release of arachidonic acid by the membrane phospholipase and metabolism by the 5-lipoxygenase pathway was examined in human polymorphonuclear leukocytes (PMNs). The 5-lipoxygenase pathway is activated when PMNs are given arachidonic acid in ethanol and there is extensive metabolism to 5-hydroxyicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4). This activation event was shown to be altere...
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ژورنال
عنوان ژورنال: Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology)
سال: 1993
ISSN: 0385-0110,1880-408X
DOI: 10.2329/perio.35.179